Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α‐Dystroglycan <i>O</i>‐Mannosylated Core M1 Glycoconjugates <i>In situ</i>

Seek a cell anchorage galectin bridge: Transforming the wildtype Galectin (Gal)-1 and -3 to tandem-repeat type variant via rational protein engineering enhanced cis-binding activity with O-Mannosylated core M1 glycopeptides of α-dystroglycan (DG). Furthermore, Gal-1 variants (but not Gal-3 variants) demonstrated trans-bridging prepared α-DG core-M1 glycoconjugates laminins in situ carbohydrate-protein interactions. Thus, its are exciting candidates for treating several forms muscular dystrophy. More information can be found Research Article by H. Kaltner, Hinou, et al.